In 1637 he and his wife and four small children, along with quite a few of their neighbors, left their homes in England behind forever for a new life in New England. Although his wife and children would prosper in their new home, William was dead within four years of his arrival.
William took the freedman's oath on 13 May 1640. In order to do so, William had to be a full member of the church at Roxbury. Being a freedman would enable a man to participate fully in the running of the new colony but by 1640 William was dying. He suffered from a lingering illness which lasted the better part of a year, as recorded by the Reverend John Eliot, minister of Roxbury. He wrote that William "fell into a consumption to which he had been long inclined, he lay near a year sick". He described William as poor but God opened the hearts of his nabs (neighbors?) to him, yet he never wanted". His death was recorded on the 26th of the 11th month of the year 1641. This is often interpreted as 26 November 1641, but if Rev. Eliot was referring to the 11th month of the Puritan calendar than the date is actually 26 Jan 1641/2. The Puritan calendar year began on March 25th not January 1.
Annis married for a third and last time on 9 August 1660 to John Parmenter, widower, deacon of the church, and resident of Sudbury. His wife had died the previous April. He died, aged 83, in 1671 in Roxbury. Annis lived another 12 years, dying in March of 1683. She was recorded as "old mother Parmiter, a blessed saint".
Someone on ancestry.com has William Chandler as Sir William Le Chaundler and his wife Annis is called Lady Annis. In this same tree George Abbott who married their daughter Hannah is called Sir George Abbott and they include a portrait of him. While this is good for a giggle, it is pure fabrication. The portrait is actually of George Abbott who was at one time the Archbishop of Canterbury, he died in 1633.